Nonimmunoselected Intrastrain Genetic Variation Detected In Pairs Of Highyielding Influenza A (H3N2) Vaccine And Parental Viruses
Identifieur interne : 001D96 ( Main/Exploration ); précédent : 001D95; suivant : 001D97Nonimmunoselected Intrastrain Genetic Variation Detected In Pairs Of Highyielding Influenza A (H3N2) Vaccine And Parental Viruses
Auteurs : Xiyan Xu [États-Unis] ; Edwin D. Kilbourne [États-Unis] ; Henrietta E. Hall [États-Unis] ; Nancy J. Cox [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1994.
Abstract
Seven influenza A (H3N2) high-yielding vaccine candidate strains were examined. Antigenic analysis revealed that 5 of the strains could be distinguished antigenically from their corresponding wild type parent viruses. Comparative sequence data for the HAl domains ofthe HA (hemagglutinin) genes for these 5 high-yielding viruses and the corresponding wild type parents demonstrated one to three amino acid substitutions within each virus pair, with at least one amino acid change being located in a previously defined antigenic site. Comparison of the HA sequences of the 2 antigenically indistinguishable virus pairs revealed no amino acid differences in I and one amino acid change in the other. Examination of I additional wild type virus, A/Guangdong/39/89, and its three high-yielding derivatives obtained either by serial egg passage or by reassortment revealed an additive effect of the HA and M genes in creating the high-yielding phenotype.
Url:
DOI: 10.1093/infdis/170.6.1432
Affiliations:
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Antigenic analysis revealed that 5 of the strains could be distinguished antigenically from their corresponding wild type parent viruses. Comparative sequence data for the HAl domains ofthe HA (hemagglutinin) genes for these 5 high-yielding viruses and the corresponding wild type parents demonstrated one to three amino acid substitutions within each virus pair, with at least one amino acid change being located in a previously defined antigenic site. Comparison of the HA sequences of the 2 antigenically indistinguishable virus pairs revealed no amino acid differences in I and one amino acid change in the other. Examination of I additional wild type virus, A/Guangdong/39/89, and its three high-yielding derivatives obtained either by serial egg passage or by reassortment revealed an additive effect of the HA and M genes in creating the high-yielding phenotype.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Xu, Xiyan" sort="Xu, Xiyan" uniqKey="Xu X" first="Xiyan" last="Xu">Xiyan Xu</name></region><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><name sortKey="Hall, Henrietta E" sort="Hall, Henrietta E" uniqKey="Hall H" first="Henrietta E." last="Hall">Henrietta E. Hall</name><name sortKey="Kilbourne, Edwin D" sort="Kilbourne, Edwin D" uniqKey="Kilbourne E" first="Edwin D." last="Kilbourne">Edwin D. Kilbourne</name><name sortKey="Xu, Xiyan" sort="Xu, Xiyan" uniqKey="Xu X" first="Xiyan" last="Xu">Xiyan Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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